Brain ultrastructure and the neurovascular unit

Tools

About

Søren Grubb is a neuroscientist and Educational Manager at Neuroscience Academy Denmark, with a background in neurovascular research and cardiac electrophysiology.

This site hosts research tools built on open, publicly licensed electron microscopy datasets. The work here is carried out independently of, and in addition to, that role.

Selected publications

• Ultrastructure of precapillary sphincters and the neurovascular unit Vascular Biology 5, VB-23-0011 (2023). doi:10.1530/vb-23-0011
• Microglia contact cerebral vasculature through gaps between astrocyte endfeet Morris, Foster, Sutherland & Grubb. J Cereb Blood Flow Metab 44(12), 1472–1486 (2024). doi:10.1177/0271678X241280775
• Public volume electron microscopy data: an essential resource to study the brain microvasculature Frontiers in Cell and Developmental Biology (2022). doi:10.3389/fcell.2022.849469
• Pericyte and endothelial primary cilia and centrioles have disparate organization across the brain microvasculature Grubb, Chaddha, Lippincott-Schwartz, Ott & Mughal. bioRxiv (2025). doi:10.1101/2025.11.19.689283 — preprint, not yet peer-reviewed
• Ultrastructure of the brain waste-clearance pathway bioRxiv (2023). doi:10.1101/2023.04.14.536712 — preprint, not yet peer-reviewed

Data & attribution

Cell positions, segmentation and type predictions come from the MICrONS minnie65 mouse visual cortex dataset, released under CC-BY by the MICrONS Consortium (Nature 640, 435–447, 2025). Hand-verified identifications, traced vessel outlines and traced pia/white-matter surfaces are original work from this lab.